While the isotype may be of paramount importance for the function and performance of your monoclonal antibody, the process of hybridoma development may not offer a choice of isotypes. It is however possible to change the isotype of your antibody. For example, from IgG1 to IgG2a.
Isotype switching is a rather straight forward procedure. It requires cloning and sequencing of variable region cDNA, grafting the sequence information onto the required framework, synthesising the resulting gene and finally producing the recombinant antibody in a mammalian expression system.
We offer to perform isotype switching of your antibody, either as a stand-alone service or as part of the monoclonal antibody development service.
Innovagen was founded in 1992. Since then we have been providing the scientific community with high quality research antibodies and their related services. Our experience and dedicated customer service will ensure that your best interests are looked after when you turn to us with your antibody project.
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